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Optical Aptamer Biosensors for In-Vivo Sensing (2023-087)
Electrochemical aptamer sensors can identify the presence and/or concentration of a target analyte of interest via the use of an aptamer sequence that specifically binds to the analyte of interest. These sensors include aptamers attached to an electrode or an optical surface, wherein each of the aptamers has a redox active molecule or a fluorescent...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Jason Heikenfeld
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences
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Sensor for Early Detection of Post-Surgical Infection (2022-110)
Prosthetic Joint Infection (PJI) is an infection that involves the joint prosthesis and adjacent tissue caused by Gram-positive cocci and other bacteria. These infections typically cause pain, redness, and swelling at the joint, and if untreated, can even result in disability and impaired quality of life. For the geriatric population, PJI has led...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Jiaxin Jiang, Krithika Sureshkumar, Chandrashekhar Choudhary, Henry Sagi, Chia-Ying Lin, Michael Archdeacon, Tao Li
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences
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Rapid 3d-Bioprinting of Vascular Tissue Models for Drug Discovery (2022-081)
Preclinical drug studies typically rely on animal experimentation. However, due to the decreasing drug attrition rate, new cell culture models, known as microphysiological systems (MPSs) or organs-on-chips (OOCs), have been developed for preliminary drug testing.
MPSs allow for the recreation of human tissue-tissue interfaces, and consist of a base...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Riccardo Barrile
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics > Biomaterials, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Therapeutics > Small Molecule, Technology Classifications > Life Sciences
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Biodegradable Implants for Long-term Antibody Drug Delivery (2022-050)
Monoclonal antibodies have become increasingly valuable for treatment of a variety of diseases, such as age-related macular degeneration, various cancers, and inflammatory diseases. While these drugs have proven effective, they have a short half-life, and thus require repeated injections on a biweekly, monthly, or bimonthly basis which places a significant...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Thomas (TJ) Waterkotte, Yoonjee Park
Keywords(s):
Category(s): Technology Classifications > Advanced Materials > Healthcare-related materials, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Therapeutics > Protein Therapies, Technology Classifications > Life Sciences, Technology Classifications > Advanced Materials, Technology Classifications > Life Sciences > Therapeutics
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Patient-specific biodegradable drug delivery (2022-035)
Biomaterial implants fabricated from synthetic polymers have been extensively used in regenerative medicine applications and are regularly formulated into erodible drug delivery systems or degradable scaffolds. These implants are most commonly degraded by hydrolysis. While these materials can be effective, their degradation rates are pre-determined;...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Karina Bruce, Dylan Marques, Alan Fullenkamp, John Martin
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics > Biomaterials, Technology Classifications > Life Sciences > Regenerative Medicine, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
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Improved Potency of Drugs and Pesticides via Novel Difluoromethylation Methods (2022-016)
Installing fluorine and fluorine-containing groups has become a commonly used tactic to improve the potency of pharmaceutical and agrochemical agents. In particular, difluoromethyl (CF2H) and trifluoromethyl (CF3) groups act as lipophilic hydrogen bond donors and thus potential bioisosteres for hydroxyl, amino, or thiol groups. As a result, CF2H and...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Wei Liu
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Agriculture
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Non-Invasive Hydrogen Monitoring Device to Assess Gut Health (2021-114)
Humans do not produce hydrogen gas; however, many microbes found in the human gut do. The hydrogen produced from gut microbiota can have beneficial effects, but an excess of hydrogen can also have harmful effects on the human host, as it is proposed to be associated with various gastrointestinal disorders.
Hydrogen gas produced by the microbes in the...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Senu Apewokin, Michael Smith, Peng Zhang, Racheal Wilkinson, Sarah Pixley Bell, William Heineman
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Digestive, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Diagnostics
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Novel Calibration Phantom for Improved Proton Radiotherapy Outcomes (2020-143)
Proton radiotherapy involves precise delivery of high doses of radiation to treat cancer. Protons travel a certain distance into the tissue, and energy is released only at the target site. This makes proton radiotherapy more precise than traditional radiation treatment, and less destructive to surrounding healthy tissue. However, full optimization of...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Peter Sandwall, Michael Lamba, Samuel Glover, Henry Spitz, Jimmy Stringer
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Medical Devices
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Syringe Based Rapid Processor for Small Biopsies (2019-050)
There is a significant unmet need in the field of pathology for rapid processing of small biopsies which allows clinicians to make a preliminary diagnosis prior to patient discharge. The current methodology to process “immediate reads” involves running a standard tissue processor coupled with traditional embedding technique, which are both...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Paul Lee
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences
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Single Molecule Epigenetic Localization (2019-047)
DNA epigenetic modifications play important functions in a broad range of physiological and pathological processes and their dysregulation can lead to various human diseases. 5-hydroxymethylcytosine (5hmC) is one of the major mammalian DNA epigenetic modifications and is believed to be a gene activation marker in development and disease. Recently, 5hmC...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Chunxiao Song, Jiajie Diao
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Other Life Sciences
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