Improved Potency of Drugs and Pesticides via Novel Difluoromethylation Methods (2022-016)
Installing fluorine and fluorine-containing groups has become a commonly used tactic to improve the potency of pharmaceutical and agrochemical agents. In particular, difluoromethyl (CF2H) and trifluoromethyl (CF3) groups act as lipophilic hydrogen bond donors and thus potential bioisosteres for hydroxyl, amino, or thiol groups. As a result, CF2H and...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Wei Liu
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Agriculture
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