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Rapid 3d-Bioprinting of Vascular Tissue Models for Drug Discovery (2022-081)
Preclinical drug studies typically rely on animal experimentation. However, due to the decreasing drug attrition rate, new cell culture models, known as microphysiological systems (MPSs) or organs-on-chips (OOCs), have been developed for preliminary drug testing.
MPSs allow for the recreation of human tissue-tissue interfaces, and consist of a base...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Riccardo Barrile
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics > Biomaterials, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Therapeutics > Small Molecule, Technology Classifications > Life Sciences
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Glioma Treatment Utilizing Ep2 Antagonists (118014)
With 17,000 new cases diagnosed each year in the United States, malignant gliomas account for about 80% of all primary malignant brain tumors, with 82% of these cases classified as a grade IV tumor—glioblastoma multiforme (GBM). The median survival time of GBM patients from diagnosis with treatment is only about 15 months. Malignant gliomas are...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Jianxiong Jiang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Diseases & Disorders > Neurologic, Technology Classifications > Life Sciences > Therapeutics > Small Molecule, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders
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Small Molecule Prolactin Receptor Inhibitors for Treatment of Cancers and Pain Disorders (117-018)
Each year, over a million women worldwide are diagnosed with breast cancer, accounting for 25% of all female cancers. About 1 in 8 women are predicted to develop this disease during her lifetime. Over the last two decades, single and combination chemotherapy, based on results from clinical trials, has led to a considerable reduction in morbidity and...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Armen Akopian, Abraham Domb, Edward Merino, Eric Hugo, Nira Ben-Jonathan
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Diseases & Disorders > Neurologic, Technology Classifications > Life Sciences > Therapeutics > Small Molecule, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Therapeutics
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Letrozole Treatment of Primary Brain Tumors (113-035)
Dr. Pankaj Desai has discovered that aromatase inhibitors usually used in the treatment of estrogen receptor (ER+) positive breast cancer surprisingly exhibited potent activity against brain tumors in various preclinical models.
Treatment of primary and metastatic brain tumors remains one of the most formidable challenges in oncology. According to...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Nimita Dave, Pankaj Desai
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Therapeutics > Small Molecule, Technology Classifications > Life Sciences > Therapeutics > Repurposed, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Therapeutics
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