Accelerated Cardiac Differentiation of Induced Pluripotent Stem Cells by Electrical Stimulation

 

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Technology Overview

Dr. Wang and his team at the University of Cincinnati have developed a method for the accelerated differentiation of iPSCs into cardiac cells through electrical stimulation. By avoiding the need to add certain exogenous growth factors, this method is less expensive, more reproducible, and more scalable than standard methods currently in use.

Background

Stem cells are pluripotent cells with remarkable potential to develop into many different cell types in the body during early life and growth. Stem cells hold promise for regenerative medicine and cell therapy, especially in fields where more personalized medicine approaches are becoming increasingly predominant. For example, a wide variety of progenitor/stem cell therapies are recognized as a promising strategy to repair damaged tissue, such as an ischemic damaged heart. Although stem cells carry promise, there are still challenges. Current protocols for differentiating induced pluripotent stem cells (iPSCs) into mature cardiomyocytes are expensive, poorly reproducible, and limited in terms of scale-up.

Advantages and Benefits
  • Faster generation of Cardiac Cells
  • More reproducible results compared to standard methods
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Patents
Title Country Serial No. Patent No. File Date Issued Date
Methods for Accelerated and Enhanced Cardiac Differentiation of IPS Cells by Electrical Stimulation United States 14/995,997 9,868,938 1/14/2016 1/16/2018
Methods for Accelerated and Enhanced Cardiac Differentiation of EPS Cells by Electrical Stimulation United States 15/837,366 10,513,688 12/11/2017 12/24/2019
Other Media
Inventor(s)
Contact
Jill Uhl
Sr. Licensing Associate, Life Sciences
Lead Inventor
Yigang Wang
Keywords
Cardiac Differentiation, Electrical Stimulation, Healthcare, Induced Pluripotent Stem Cells (iPSCs), Regenerative Medicine,
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