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Novel Treatment Strategies for Pancreatic Cancer using Recombinant Acid Sphingomyelinase (2023-072)
Pancreatic Adenocarcinoma (PDAC) is one of the most common cancers worldwide. Despite decade of advancement and research into the multimodal care of PDAC, the outlook remains grim. The majority of patients with PDAC present with metastatic disease at time of diagnosis. Only a minority of patients present with potentially respectable disease and even...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Gregory Wilson, Erich Gulbins, Syed Ahmad
Keywords(s): Acid Sphingomyelinase, Cancer, Healthcare, Pancreatic Adenocarcinoma (PDAC), Tumor Progression
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Diseases & Disorders
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Immunotherapeutic Phospholipid for Cancer Treatment (2023-012)
A hallmark feature of malignant cell growth is the presence of an immunosuppressive tumor microenvironment (TME). Cancer cells have evolved mechanisms that promote the escape from the host immune attack which sustains tumor growth. Reversal of immunosuppression in the TME is now considered a powerful approach for cancer treatment.
The TME is a complex...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Xiaoyang Qi
Keywords(s): Cancer, Healthcare, Immune System, Immunotherapeutic Phospholipid, Tumor Microenvironment (TME)
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Diseases & Disorders > Autoimmune, Technology Classifications > Life Sciences > Therapeutics > Biomaterials, Technology Classifications > Life Sciences > Therapeutics
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CXCL-1 Inhibits Natural Killer Cell Cytoxocity
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Dr. Wise-Draper and her team discovered that CXCL1 is inhibited by metformin in natural killer (NK) cells which in turn results in enhanced NK cellular cytotoxicity. This inhibition of NK cytotoxicity is a new and novel function of CXCL1. NK cells are an...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): McKenzie Crist, Trisha Wise-Draper
Keywords(s): Cancer, CXCL-1 Inhibition, Healthcare, Immune System, Metformin, Natural Killer Cell Cytoxocity
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer
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Telehealth Drone (2020-141)
Due to the increase in lifespan along with the growing older adult population, the home healthcare industry is experiencing substantial shortages of health care workers. This comes at a time when home- and community-based care for older adults is a preferable alternative to institutional care. This is due to the promotion of independent living for older...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Victoria Wangia-Anderson, Seung-Yeon Lee, Manish Kumar, Deborah Sampsel
Keywords(s): Drones, Healthcare, Telehealth
Category(s): Technology Classifications > Life Sciences > Medical Devices, Technology Classifications > Life Sciences
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A Prognostic Test for Early-Stage Breast Lesions
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Dr. Georg F. Weber, Professor in the College of Pharmacy has developed a test to determine the risk for pre-malignant lesions to turn into breast cancer. This novel assessment utilizes variants of the progression mediator osteopontin...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Georg Weber
Keywords(s): Biological Assessment, Diagnostic Testing, Early-Stage Breast Lesions, Healthcare, Osteopontin Variants
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences
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Accelerated Cardiac Differentiation of Induced Pluripotent Stem Cells by Electrical Stimulation
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Dr. Wang and his team at the University of Cincinnati have developed a method for the accelerated differentiation of iPSCs into cardiac cells through electrical stimulation. By avoiding the need to add certain exogenous growth factors,...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Ruilian Ma, Ha Won Kim, Yi-Gang Wang
Keywords(s): Cardiac Differentiation, Electrical Stimulation, Healthcare, Induced Pluripotent Stem Cells (iPSCs), Regenerative Medicine
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Regenerative Medicine
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Breath analysis for disease diagnosis
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Drs. Anastasios Angelopoulos and Jonathan A. Bernstein have developed a new optical sensor that could enable nearly instantaneous chemical measurement of human breath. The tool is simple and non-invasive, which...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Jonathan Bernstein, Anastasios Angelopoulos
Keywords(s): Biological Biomarker, Breath Analysis, Chemical Detection, Disease Diagnosis, Healthcare
Category(s): Technology Classifications > Sensors > Health-related Sensors, Technology Classifications > Sensors > Agribusiness-Environmental, Technology Classifications > Life Sciences > Diseases & Disorders > Diabetes-related, Technology Classifications > Sensors, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders
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New method for treating autoimmune diseases
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Dr. Laura Conforti has discovered a way that uses lipid-derived nanovesicles functionalized with antibodies against membrane proteins expressed only on the surfaces of the subset of immune cells involved in the pathology...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Yeoheung Yun, Laura Conforti
Keywords(s): Autoimmune Diseases Treatment, Healthcare, Kv1.3 Ion Channel Targeting, Lipid-Derived Nanovesicles, RNAi Drug Delivery
Category(s): Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Diseases & Disorders > Autoimmune, Technology Classifications > Life Sciences > Therapeutics > Biomaterials, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders
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Alternative to antibiotic treatment
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A team of researchers, led by Dr. Peng Zhang, a world-renowned expert in photodynamic therapy, has developed a safe photosensitizer gel which is an effective alternative to antibiotics for treating acne. The gel is currently in the early stages of development,...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Bo Hu, Hong Tang, Peng Zhang
Keywords(s): Acne Treatment, biological, Healthcare, Photodynamic Therapy, Photosensitizer Gel
Category(s): Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences
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