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Novel Method for Pleurodesis and Delivery of Drugs to Lung and Pleural Space
Pleurodesis is a method used to treat pathological collection of air or liquid in the chest cavity, termed pneumothorax (collapsed lung) or pleural effusion (which can be malignant or benign), respectively, which pose daily management challenges in virtually every major hospital. Pleurodesis is accomplished by interventions that induce fusion of the...
Published: 9/14/2023
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Updated: 9/14/2023
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Inventor(s): Francis McCormack, Yusuke Tanaka
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Respiratory, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences
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Optical Aptamer Biosensors for In-Vivo Sensing (2023-087)
Electrochemical aptamer sensors can identify the presence and/or concentration of a target analyte of interest via the use of an aptamer sequence that specifically binds to the analyte of interest. These sensors include aptamers attached to an electrode or an optical surface, wherein each of the aptamers has a redox active molecule or a fluorescent...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Jason Heikenfeld
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences
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Novel Treatment Strategies for Pancreatic Cancer using Recombinant Acid Sphingomyelinase (2023-072)
Pancreatic Adenocarcinoma (PDAC) is one of the most common cancers worldwide. Despite decade of advancement and research into the multimodal care of PDAC, the outlook remains grim. The majority of patients with PDAC present with metastatic disease at time of diagnosis. Only a minority of patients present with potentially respectable disease and even...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Gregory Wilson, Erich Gulbins, Syed Ahmad
Keywords(s): Acid Sphingomyelinase, Cancer, Healthcare, Pancreatic Adenocarcinoma (PDAC), Tumor Progression
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Diseases & Disorders
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Novel Skin Prick Test Device (2023-045)
Immediate hypersensitivity reactions are immune-mediated reactions to proteins and responsible for symptoms of allergic rhinitis, food allergy, and anaphylaxis. Immediate hypersensitivities are mediated by allergic IgE antibodies that inappropriately recognize a foreign protein as immunogenic. To test for the presence of IgE antibodies, a skin prick...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Yashu Dhamija
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Medical Devices, Technology Classifications > Life Sciences
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Inhibition of Airway Hyperresponsivenes by Interleukin 31 Receptor Alpha in Asthma (2023-038)
Asthma is a chronic inflammatory airway characterized by airway hyperresponsiveness (AHR), airway inflammation, and goblet cell hyperplasia. AHR or the excessive response of the airways to a variety of stimuli is one of the cardinal features of asthma. AHR is a major cause of hospitalization, morbidity, and morality in allergic asthma; however, the...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Satish Madala, Santoshi Akkenapally
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Diseases & Disorders > Respiratory
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Calcium Activated Cl- Channel in HEK 293 Cells (102-009)
Ion Channels play a crucial role in many diseases, most notably in cystic fibrosis. A calcium-activated pathway for Cl- may play an important role in disease severity. However, little is known of the physiological and pharmacological properties of this ion channel.
To study this protein, Dr. Cuppoletti has transfected HEK 293 cell line with a human...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): John Cuppoletti
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences
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Therapy for Addiction
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UC researchers have developed a monoclonal antibody that recognizes and effectively binds cocaine. By administering this antibody, cocaine concentrations are much lower in the brain, which aid individuals battling drug...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Nils Lonberg, Denise Williams, W. James Ball, Andrew Norman
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Therapeutics > Protein Therapies, Technology Classifications > Life Sciences > Diseases & Disorders > Neurologic, Technology Classifications > Life Sciences
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A stable cell line expressing Human L-type cardiac calcium channel alpha 1C clone (100-058)
A number of Ca2+ channel genes have been cloned in the past decade. Expression of these genes for the purpose of studying function has been achieved in Xenopus oocytes and later, in various mammalian cells.
We have introduced the human Ca2+ channel alpha 1C subunit cDNA into human embryonic kidney cells (HEK293) via DNA-mediated gene transfer procedure....
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Gyula Varadi, Arnold Schwartz
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences
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Compounds to Treat Obesity (104-010)
Obesity is now considered as a global epidemic with over one billion people being overweight. About $33 billion is being spent each year in USA on weight reduction products. To date no satisfactory drug is available to control obesity. Therefore, millions of dollars are spent each year towards the development of new treatments to fight this epidemic.
Neuropeptide...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Ambikaipakan Balasubramanium
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics > Biomaterials, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Diseases & Disorders > Cardiovascular, Technology Classifications > Life Sciences > Diseases & Disorders > Diabetes-related
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Immunotherapeutic Phospholipid for Cancer Treatment (2023-012)
A hallmark feature of malignant cell growth is the presence of an immunosuppressive tumor microenvironment (TME). Cancer cells have evolved mechanisms that promote the escape from the host immune attack which sustains tumor growth. Reversal of immunosuppression in the TME is now considered a powerful approach for cancer treatment.
The TME is a complex...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Xiaoyang Qi
Keywords(s): Cancer, Healthcare, Immune System, Immunotherapeutic Phospholipid, Tumor Microenvironment (TME)
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Diseases & Disorders > Autoimmune, Technology Classifications > Life Sciences > Therapeutics > Biomaterials, Technology Classifications > Life Sciences > Therapeutics
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