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Calcium Activated Cl- Channel in HEK 293 Cells (102-009)
Ion Channels play a crucial role in many diseases, most notably in cystic fibrosis. A calcium-activated pathway for Cl- may play an important role in disease severity. However, little is known of the physiological and pharmacological properties of this ion channel.
To study this protein, Dr. Cuppoletti has transfected HEK 293 cell line with a human...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): John Cuppoletti
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences
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A stable cell line expressing Human L-type cardiac calcium channel alpha 1C clone (100-058)
A number of Ca2+ channel genes have been cloned in the past decade. Expression of these genes for the purpose of studying function has been achieved in Xenopus oocytes and later, in various mammalian cells.
We have introduced the human Ca2+ channel alpha 1C subunit cDNA into human embryonic kidney cells (HEK293) via DNA-mediated gene transfer procedure....
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Gyula Varadi, Arnold Schwartz
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences
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Microfluidic Device Design for 3d Neural Circuit Modeling (2021-056)
The study of neural circuits is important to help understand brain function and the causes of neurological complications. Compartmentalized microfluidic devices provide an in vitro environment for effective modeling and studying neural circuits, allowing for a better understanding of how neurons interact with each other by culturing neurons in separate...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Ziyuan Guo, Tianshuo Wang, Tao Li
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Research Tools
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One Step Digestion of Nucleic Acids to Nucleosides (118-043)
The analysis of RNA, both oligomeric and monomeric, occurs primarily through mass spectrometry (MS). Over three decades of RNA analysis via MS has resulted in a plethora of knowledge regarding RNA. However, as the MS techniques have improved, the methods for prepping RNA for analysis have not. A method developed over 20 years ago still remains the primary...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Patrick Limbach, Manasses Jora, Balasubrahmanyam Addepalli, Robert Ross
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences > Other Life Sciences, Technology Classifications > Life Sciences
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Nanopipette Device for Label-Free, Rapid Liquid Cancer Biopsy (117-042)
Early cancer detection is crucial for survival. Many cancer screening methods and biopsies, though, require complex and invasive surgical procedures causing cancers to go undetected during the early stages. Exosomes, or cell-secreted nanoscale extracellular vesicles, contain biomarkers that indicate cancers and other diseases, and they are constantly...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Leyla Esfandiari
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Medical Devices, Technology Classifications > Life Sciences
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Mouse Model for Angiosarcoma and Lymphangiosarcoma (116-022)
Dr. Jun-Lin Guan and his lab have developed a research tool for modeling angiosarcoma and lymphangiosarcoma.
This research tool is a genetically-engineered mouse model, that replicates all the main features of human angiosarcoma and lymphangiosarcoma, including invasion and metastasis. A technique for isolating primary tumor cells from the mice has...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Fuchun Yang, Shaogang Sun, Jun-Lin Guan
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences
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Mouse Strain B6.FVB-Tg(GNAT2-Dta)98Wwk/J (108-112)
Mice hemizygous for this "Trc-Tox176" transgene (also called "h-GNAT2pro-DTA") are viable and fertile. Expression of diphtheria toxin (DTA) from the transgene is similar to that of endogenous GNAT2, leading to ablation of both rod and cone photoreceptor development in the ventral retina (the abnormality is a result of abnormal cellular...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Shao-Ling Fong, Sai-Xia Ying, Winston Kao
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences
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Drug/Food Self-Administration v.2.23 (108-104)
This software and accompanying bioassay measure the pharmacodynamic (PD) and pharmacokinetics (PK) properties of a psychotropic compounds. Three properties of the compound can be measured: bioavailability, potency, and half-life. The compounds potential for abuse/addiction can also be quantified.
Conventional analytical methods for measuring PD and...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Vladimir Tsibulski, Andrew Norman
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Software, Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences
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Mammary Gland estrogen receptor knock-out mouse (108-075)
Dr. Sohaib Khan, a Professor in the Department of Cancer and Cell Biology at the University of Cincinnati, has developed a conditional knockout mouse that keeps the estrogen receptor in all tissues except the mammary tissue, which allows scientists to study the role the receptor plays in breast development and abnormalities such as breast cancer or...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Yuxin Feng, Sohaib Khan
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences
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RU360 (106-087)
A cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM). Specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 M of Ru360 for 30 min). Does not affect other cellular Ca2+...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Mohammed Matlib
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Research Tools, Technology Classifications > Life Sciences
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