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Novel Treatment Strategies for Pancreatic Cancer using Recombinant Acid Sphingomyelinase (2023-072)
Pancreatic Adenocarcinoma (PDAC) is one of the most common cancers worldwide. Despite decade of advancement and research into the multimodal care of PDAC, the outlook remains grim. The majority of patients with PDAC present with metastatic disease at time of diagnosis. Only a minority of patients present with potentially respectable disease and even...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Gregory Wilson, Erich Gulbins, Syed Ahmad
Keywords(s): Acid Sphingomyelinase, Cancer, Healthcare, Pancreatic Adenocarcinoma (PDAC), Tumor Progression
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Diseases & Disorders
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Immunotherapeutic Phospholipid for Cancer Treatment (2023-012)
A hallmark feature of malignant cell growth is the presence of an immunosuppressive tumor microenvironment (TME). Cancer cells have evolved mechanisms that promote the escape from the host immune attack which sustains tumor growth. Reversal of immunosuppression in the TME is now considered a powerful approach for cancer treatment.
The TME is a complex...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Xiaoyang Qi
Keywords(s): Cancer, Healthcare, Immune System, Immunotherapeutic Phospholipid, Tumor Microenvironment (TME)
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Diseases & Disorders > Autoimmune, Technology Classifications > Life Sciences > Therapeutics > Biomaterials, Technology Classifications > Life Sciences > Therapeutics
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CXCL-1 Inhibits Natural Killer Cell Cytoxocity
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Dr. Wise-Draper and her team discovered that CXCL1 is inhibited by metformin in natural killer (NK) cells which in turn results in enhanced NK cellular cytotoxicity. This inhibition of NK cytotoxicity is a new and novel function of CXCL1. NK cells are an...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): McKenzie Crist, Trisha Wise-Draper
Keywords(s): Cancer, CXCL-1 Inhibition, Healthcare, Immune System, Metformin, Natural Killer Cell Cytoxocity
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer
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Drug Delivery Device For Treatment of Brain Tumors (2022-069)
Glioblastoma (GBM) is the most common and aggressive form of brain cancer in adults. Due to the rapid growth rate and infiltrative nature of the tumor, currently available therapies for treating GBM have increased median survival to only around fifteen months.
GBM resistance to therapies leads to poor outcomes in patients with GBM and eventually patient...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Betty Tyler, Henry Brem, Safwan Alomari, Daewoo Han, Andrew Steckl
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
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Three-Dimensional Echo Decorrelation Imaging for Thermal Ablation of Liver Cancer (2022-008)
Liver cancer is common in the United States, with over 36,000 Americans receiving a diagnosis of liver cancer each year. Thermal ablation, including radiofrequency and microwave ablation (RFA and MWA) is a useful treatment for liver cancer, but patient outcomes are inferior to that of surgery. Monitoring and controlling thermal ablation would overcome...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Peter Grimm, Elmira Ghahramani Z., T Mast
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Medical Devices
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Novel Calibration Phantom for Improved Proton Radiotherapy Outcomes (2020-143)
Proton radiotherapy involves precise delivery of high doses of radiation to treat cancer. Protons travel a certain distance into the tissue, and energy is released only at the target site. This makes proton radiotherapy more precise than traditional radiation treatment, and less destructive to surrounding healthy tissue. However, full optimization of...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Peter Sandwall, Michael Lamba, Samuel Glover, Henry Spitz, Jimmy Stringer
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Medical Devices
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Single Molecule Epigenetic Localization (2019-047)
DNA epigenetic modifications play important functions in a broad range of physiological and pathological processes and their dysregulation can lead to various human diseases. 5-hydroxymethylcytosine (5hmC) is one of the major mammalian DNA epigenetic modifications and is believed to be a gene activation marker in development and disease. Recently, 5hmC...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Chunxiao Song, Jiajie Diao
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Other Life Sciences
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Glioma Treatment Utilizing Ep2 Antagonists (118014)
With 17,000 new cases diagnosed each year in the United States, malignant gliomas account for about 80% of all primary malignant brain tumors, with 82% of these cases classified as a grade IV tumor—glioblastoma multiforme (GBM). The median survival time of GBM patients from diagnosis with treatment is only about 15 months. Malignant gliomas are...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Jianxiong Jiang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Diseases & Disorders > Neurologic, Technology Classifications > Life Sciences > Therapeutics > Small Molecule, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders
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R-2hg-Based Therapeutic Strategies Targeting Cancers (117-029)
According to the reports of the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program, in 2016 there were an estimated 414,773 people living with leukemia in the United States. Additionally, in 2016, there were an estimated 165,813 people living with brain and other nervous system cancer in the United States. With the...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Rui Su, Jianjun Chen
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomedical, Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Diseases & Disorders > Neurologic, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders
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Small Molecule Prolactin Receptor Inhibitors for Treatment of Cancers and Pain Disorders (117-018)
Each year, over a million women worldwide are diagnosed with breast cancer, accounting for 25% of all female cancers. About 1 in 8 women are predicted to develop this disease during her lifetime. Over the last two decades, single and combination chemotherapy, based on results from clinical trials, has led to a considerable reduction in morbidity and...
Published: 8/30/2023
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Updated: 8/30/2023
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Inventor(s): Armen Akopian, Abraham Domb, Edward Merino, Eric Hugo, Nira Ben-Jonathan
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diseases & Disorders > Cancer, Technology Classifications > Life Sciences > Diseases & Disorders > Neurologic, Technology Classifications > Life Sciences > Therapeutics > Small Molecule, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diseases & Disorders, Technology Classifications > Life Sciences > Therapeutics
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